Oven Baked 4-Ingredient Meatball Sub Casserole
The Oven Baked 4-Ingredient Meatball Sub Casserole is a delicious and easy dish perfect for a family dinner or a gathering. With just four simple ingredients, this casserole brings together flavors that everyone loves. It’s comforting, cheesy, and packed with hearty meatballs, making it a great choice for both kids and adults.
Why Make This Recipe
This recipe is great because it requires minimal effort and only a few ingredients. If you’re in a rush or not feeling like spending hours in the kitchen, this casserole is ideal. You can have a warm meal on the table in about an hour without needing fancy cooking skills. Plus, it’s tasty and filling!
How to Make Oven Baked 4-Ingredient Meatball Sub Casserole
Ingredients:
- 1 bag (26 oz) frozen beef meatballs
- 1 jar (24 oz) pasta sauce
- 8 slices provolone cheese
- 1 can (16 oz) refrigerated biscuits, quartered
Directions:
- Preheat the oven to 375 degrees F and lightly grease a 9×13-inch baking dish.
- Spread the frozen meatballs in a single layer in the baking dish straight from the bag.
- Pour the pasta sauce evenly over the meatballs, making sure each one is well coated.
- Cover the dish tightly with foil.
- Bake covered for 40 to 45 minutes, or until the meatballs are heated through and the centers reach 165 degrees F.
- Remove the foil, arrange the quartered biscuit pieces over and around the saucy meatballs, then lay the provolone slices across the top.
- Return the dish to the oven uncovered and bake for another 10 to 15 minutes, until the biscuits are golden and the cheese is melted and bubbly.
- Let it rest for 5 minutes before serving.
How to Serve Oven Baked 4-Ingredient Meatball Sub Casserole
This casserole is best served hot, straight from the oven. You can enjoy it on its own or serve it with a side salad. For a more complete meal, add some garlic bread or vegetables.
How to Store Oven Baked 4-Ingredient Meatball Sub Casserole
Leftovers can be stored in an airtight container in the refrigerator for up to 3 days. To reheat, simply warm it in the oven until heated through. You can also microwave individual portions if you’re in a hurry.
Tips to Make Oven Baked 4-Ingredient Meatball Sub Casserole
- Feel free to add your favorite seasonings or veggies to the pasta sauce for extra flavor.
- If you prefer a different type of cheese, mozzarella or cheddar also work great.
- Ensure the biscuits are well distributed for even cooking, so they become golden all over.
Variations
You can easily customize this casserole. Consider using turkey meatballs for a lighter option or switching the pasta sauce to a marinara with added herbs. You can even add sautéed onions or peppers before baking.
FAQs
Can I use homemade meatballs instead of frozen?
Yes, you can use homemade meatballs. Just ensure they are cooked through before adding them to the casserole.Is there a vegetarian version of this recipe?
Absolutely! You can use vegetarian meatballs and a plant-based cheese to make it vegetarian-friendly.Can this be made ahead of time?
Yes, you can assemble the casserole a day in advance. Just cover it and store it in the fridge. When you’re ready to bake, you may need to add a few extra minutes to the cooking time if it’s cold from the fridge.

Oven Baked 4-Ingredient Meatball Sub Casserole
Ingredients
Method
- Preheat the oven to 375°F and lightly grease a 9x13-inch baking dish.
- Spread the frozen meatballs in a single layer in the baking dish straight from the bag.
- Pour the pasta sauce evenly over the meatballs, making sure each one is well coated.
- Cover the dish tightly with foil.
- Bake covered for 40 to 45 minutes, or until the meatballs are heated through and the centers reach 165°F.
- Remove the foil, arrange the quartered biscuit pieces over and around the saucy meatballs, then lay the provolone slices across the top.
- Return the dish to the oven uncovered and bake for another 10 to 15 minutes, until the biscuits are golden and the cheese is melted and bubbly.
- Let it rest for 5 minutes before serving.







