Preheat oven to 400°F (200°C) and place a wire rack over a baking sheet.
Prepare three shallow bowls: one with flour, salt, and pepper; one with beaten eggs; and one with Panko, Parmesan, garlic powder, paprika, and oregano.
Pat chicken tenders dry with paper towels.
Dredge each tender in flour and shake off the excess.
Dip the floured tender into the egg wash to coat completely.
Press the tender into the Panko-Parmesan mixture, ensuring a thick, even layer.
Arrange tenders on the wire rack and mist the tops lightly with cooking spray.
Bake for 18 to 20 minutes, or until the internal temperature reaches 165°F (74°C) and the exterior is golden brown.