Preheat oven to 400 degrees Fahrenheit (200 degrees Celsius) and line a baking sheet with a wire rack or parchment paper.
Combine Panko breadcrumbs, grated Parmesan cheese, garlic powder, onion powder, salt, and pepper in a shallow dish.
Place flour in a second shallow dish and the beaten eggs in a third shallow dish to create a breading station.
Dredge each chicken tender in flour, shaking off excess, dip into the beaten eggs, and then press firmly into the Panko mixture to coat thoroughly.
Arrange chicken tenders on the prepared baking sheet and bake for 15 to 18 minutes until the exterior is golden brown and internal temperature reaches 165 degrees Fahrenheit.
In a small mixing bowl, whisk together mayonnaise, honey, mustard, and lemon juice until the sauce is completely smooth and emulsified.
Remove chicken from the oven and serve immediately with the prepared honey mustard dip.