Prepare the sauce by whisking together Dijon mustard, honey, mayonnaise, lemon juice, and cayenne pepper in a small bowl; refrigerate until service.
Organize a standard breading station: bowl one with flour, salt, pepper, paprika, and garlic powder; bowl two with eggs and milk whisked; bowl three with Panko breadcrumbs.
Dredge each chicken strip in the seasoned flour, shaking off excess, then submerge in the egg wash, and finally press firmly into the Panko breadcrumbs to ensure total coverage.
Heat vegetable oil in a heavy-bottomed skillet to 350 degrees Fahrenheit (175 degrees Celsius).
Working in batches to avoid temperature drops, fry the chicken tenders for 3 to 4 minutes per side until the internal temperature reaches 165 degrees Fahrenheit (74 degrees Celsius).
Transfer fried tenders to a wire cooling rack set over a baking sheet to maintain crispness and allow excess oil to drain.
Serve immediately with the chilled honey mustard sauce.